Antitumor Effect of the Mannich Base(1,3-bis-((3-Hydroxynaphthalen-2-yl)phenylmethyl)urea) on Hepatocellular Carcinoma

Antitumor Effect of the Mannich Base(1,3-bis-((3-Hydroxynaphthalen-2-yl)phenylmethyl)urea) on Hepatocellular Carcinoma

The present study was designed to evaluate the antitumor effects of the synthetic Mannich base 1,3-bis-((3-hydroxynaphthalen-2-yl)phenylmethyl)urea (1,3-BPMU) against HEP-G2 hepatoma cells and diethylnitrosamine (DEN)-induced hepatocarcinoma (HCC) in albino rats. In vitro analysis results revealed t...

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Bibliographic Details
Main Authors: Vadanasundari Vedarethinam, Karthik Dhanaraj, Soundharrajan Ilavenil, Mariadhas Valan Arasu, Ki Choon Choi, Naif Abdullah Al-Dhabi, Srigopalram Srisesharam, Kyung Dong Lee, Da Hye Kim, Tamilvenvendan Dhanapal, Ravikumar Sivanesan, Han Sung Choi, Young Ock Kim
Format: Article
Language:English
Published: MDPI AG 2016-05-01
Series:Molecules
Subjects:
1,3-BPMU
HEP-G2 cells
DEN
apoptosis
ultrastructure
Online Access:http://www.mdpi.com/1420-3049/21/5/632

Internet

http://www.mdpi.com/1420-3049/21/5/632

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