Methylation of histone H3 on lysine 79 associates with a group of replication origins and helps limit DNA replication once per cell cycle.

Methylation of histone H3 on lysine 79 associates with a group of replication origins and helps limit DNA replication once per cell cycle.

Mammalian DNA replication starts at distinct chromosomal sites in a tissue-specific pattern coordinated with transcription, but previous studies have not yet identified a chromatin modification that correlates with the initiation of DNA replication at particular genomic locations. Here we report tha...

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Bibliographic Details
Main Authors: Haiqing Fu, Alika K Maunakea, Melvenia M Martin, Liang Huang, Ya Zhang, Michael Ryan, RyangGuk Kim, Chii Meil Lin, Keji Zhao, Mirit I Aladjem
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-06-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC3674996?pdf=render

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http://europepmc.org/articles/PMC3674996?pdf=render

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