α1-adrenoceptor ligands inhibit chemokine receptor heteromerization partners of α1B/D-adrenoceptors via interference with heteromer formation

α1-adrenoceptor ligands inhibit chemokine receptor heteromerization partners of α1B/D-adrenoceptors via interference with heteromer formation

We reported previously that α1-adrenoceptor (α1-AR) ligands inhibit chemokine receptor (CR) heteromerization partners of α1B/D-AR. The underlying mechanisms are unknown and in vivo evidence for such effects is missing. Utilizing CCR2 and α1B-AR as prototypical partners, we observed in recombinant sy...

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Bibliographic Details
Main Authors: Xianlong Gao, Garrett A. Enten, Michelle Y. McGee, McWayne Weche, Matthias Majetschak
Format: Article
Language:English
Published: Elsevier 2023-04-01
Series:Pharmacological Research
Subjects:
G protein coupled receptor heteromers
Gαi coupling
β-arrestin-2
CAMP
Receptor internalization
Bioluminescence resonance energy transfer
Online Access:http://www.sciencedirect.com/science/article/pii/S1043661823000865

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http://www.sciencedirect.com/science/article/pii/S1043661823000865

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