Dynamic chromatin accessibility and transcriptome changes following PDGF-BB treatment of bone-marrow derived mesenchymal stem cells

Dynamic chromatin accessibility and transcriptome changes following PDGF-BB treatment of bone-marrow derived mesenchymal stem cells

Abstract Background Mesenchymal stem cells (MSCs) are multipotent stem cells that are under investigation for use in clinical trials because they are capable of self-renewal and differentiating into different cell types under defined conditions. Nonetheless, the therapeutic effects of MSCs have been...

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Bibliographic Details
Main Authors: Sheng Liu, Xiaona Chu, Jill L. Reiter, Xuhong Yu, Fang Fang, Patrick McGuire, Hongyu Gao, Yunlong Liu, Jun Wan, Yue Wang
Format: Article
Language:English
Published: BMC 2024-10-01
Series:BMC Genomics
Subjects:
Mesenchymal stem cells
Platelet-derived growth factor (PDGF)-BB
Chromatin accessibility
Online Access:https://doi.org/10.1186/s12864-024-10861-7

Internet

https://doi.org/10.1186/s12864-024-10861-7

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