Chelator impact: investigating the pharmacokinetic behavior of copper-64 labeled PD-L1 radioligands

Chelator impact: investigating the pharmacokinetic behavior of copper-64 labeled PD-L1 radioligands

Abstract Background Programmed cell death ligand 1 (PD-L1) plays a critical role in the tumor microenvironment and overexpression in several solid cancers has been reported. This was associated with a downregulation of the local immune response, specifically of T-cells. Immune checkpoint inhibitors...

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Bibliographic Details
Main Authors: Fabian Krutzek, Cornelius K. Donat, Sven Stadlbauer
Format: Article
Language:English
Published: SpringerOpen 2024-02-01
Series:EJNMMI Radiopharmacy and Chemistry
Subjects:
PET-tracers
Small molecules
Copper-64
Chelators
PD-L1
Online Access:https://doi.org/10.1186/s41181-024-00243-5

Internet

https://doi.org/10.1186/s41181-024-00243-5

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