Immune dysregulation, Polyendocrinopathy, Enteropathy, X-linked (IPEX) syndrome: a paradigm of immunodeficiency with autoimmunity

Immune dysregulation, Polyendocrinopathy, Enteropathy, X-linked (IPEX) syndrome: a paradigm of immunodeficiency with autoimmunity

Immune dysregulation, Polyendocrinopathy, Enteropathy, X-linked (IPEX) syndrome is a rare monogenic primary immunodeficiency (PID) due to mutations of FOXP3, a key transcription factor for naturally occurring (n) regulatory T (Treg) cells. The dysfunction of Treg cells is the main pathogenic event l...

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Bibliographic Details
Main Authors: Federica eBarzaghi, Laura ePasserini, Rosa eBacchetta
Format: Article
Language:English
Published: Frontiers Media S.A. 2012-07-01
Series:Frontiers in Immunology
Subjects:
Foxp3
IPEX
neonatal diabetes
neonatal eczema
neonatal enteropathy
Treg cells
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2012.00211/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fimmu.2012.00211/full

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