Pharmacokinetic and Pharmacodynamic Characteristics of Pelubiprofen Tromethamine vs. Pelubiprofen in Healthy Subjects

Pharmacokinetic and Pharmacodynamic Characteristics of Pelubiprofen Tromethamine vs. Pelubiprofen in Healthy Subjects

Compared to pelubiprofen, a cyclooxygenase-2-selective inhibitor, pelubiprofen tromethamine has been reported to exhibit improved solubility and absorption. Pelubiprofen tromethamine combines the anti-inflammatory effect of pelubiprofen with the gastric protective function of tromethamine salt, maki...

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Bibliographic Details
Main Authors: Yu-Jeong Son, Min-Kyu Park, Hyeon-Jeong Park, Ha-Yeon Kim, Ye-Lim Jang, Young-Sim Choi, Jun-Gi Hwang, Ji-Hyung Seo, Yu-Kyong Kim
Format: Article
Language:English
Published: MDPI AG 2023-04-01
Series:Pharmaceutics
Subjects:
phase I
comparative pharmacokinetics/pharmacodynamics
tromethamine salt
COX-2 inhibitory effect
Online Access:https://www.mdpi.com/1999-4923/15/4/1280

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https://www.mdpi.com/1999-4923/15/4/1280

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