VectorMOD: Method for Bottom-Up Proteomic Characterization of rAAV Capsid Post-Translational Modifications and Vector Impurities

VectorMOD: Method for Bottom-Up Proteomic Characterization of rAAV Capsid Post-Translational Modifications and Vector Impurities

Progress in recombinant AAV gene therapy product and process development has advanced our understanding of the basic biology of this critical delivery vector. The discovery of rAAV capsid post-translational modifications (PTMs) has spurred interest in the field for detailed rAAV-specific methods for...

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Bibliographic Details
Main Authors: Neil G. Rumachik, Stacy A. Malaker, Nicole K. Paulk
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-04-01
Series:Frontiers in Immunology
Subjects:
AAV (adeno-associated virus)
PTM (post-translational modification)
proteomics
mass spectrometry - LC-MS/MS
bottom-up approach
glycosylation
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.657795/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.657795/full

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