Trichostatin A Induced Bcl-2 Protein Level Decrease Mediated A549/CDDP Cells Apoptosis by Mitochondria Pathway

Trichostatin A Induced Bcl-2 Protein Level Decrease Mediated A549/CDDP Cells Apoptosis by Mitochondria Pathway

Background and objective The use of platinum-based combination chemotherpy remains the standard treatment for non-small cell lung cancer. However, the resistance to platinum limits further treatment clinically. Trichostatin A (TSA) is one of histone deacetylase (HDAC) inhibitors. It inhibits tumor c...

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Bibliographic Details
Main Authors: Jun WU, Chengping HU
Format: Article
Language:zho
Published: Chinese Anti-Cancer Association; Chinese Antituberculosis Association 2009-11-01
Series:Chinese Journal of Lung Cancer
Subjects:
Trichostatin A
Cisplatin-resistance
Cell cycle
Apoptosis
Mitochondrial membrane potential
Bcl-2
Online Access:http://www.lungca.org/index.php?journal=01&page=article&op=viewFile&path[]=10.3779%2Fj.issn.1009-3419.2009.11.03&path[]=1190

Internet

http://www.lungca.org/index.php?journal=01&page=article&op=viewFile&path[]=10.3779%2Fj.issn.1009-3419.2009.11.03&path[]=1190

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