An Antibiotic-Loaded Hydrogel Demonstrates Efficacy as Prophylaxis and Treatment in a Large Animal Model of Orthopaedic Device-Related Infection

An Antibiotic-Loaded Hydrogel Demonstrates Efficacy as Prophylaxis and Treatment in a Large Animal Model of Orthopaedic Device-Related Infection

Local antibiotic therapy is increasingly being recognised for its role in preventing and treating orthopaedic device-related infection (ODRI). A bioresorbable, injectable gentamicin-loaded hydrogel has been developed to deliver local antibiotics at the time of surgery with potential for both prevent...

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Bibliographic Details
Main Authors: Willemijn Boot, Andrew Lewis Foster, Olivier Guillaume, David Eglin, Tanja Schmid, Matteo D’Este, Stephan Zeiter, Robert Geoff Richards, Thomas Fintan Moriarty
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-04-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
orthopaedic device related infection
local antibiotics
hydrogel
fracture-related infection
peri-prosthetic joint infection
preclinical
Online Access:https://www.frontiersin.org/articles/10.3389/fcimb.2022.826392/full

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https://www.frontiersin.org/articles/10.3389/fcimb.2022.826392/full

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