Increased Carrier Peptide Stability through pH Adjustment Improves Insulin and PTH(1-34) Delivery In Vitro and In Vivo Rather than by Enforced Carrier Peptide-Cargo Complexation

Increased Carrier Peptide Stability through pH Adjustment Improves Insulin and PTH(1-34) Delivery In Vitro and In Vivo Rather than by Enforced Carrier Peptide-Cargo Complexation

Oral delivery of therapeutic peptides is hampered by their large molecular size and labile nature, thus limiting their permeation across the intestinal epithelium. Promising approaches to overcome the latter include co-administration with carrier peptides. In this study, the cell-penetrating peptide...

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Bibliographic Details
Main Authors: Mie Kristensen, Ragna Guldsmed Diedrichsen, Valeria Vetri, Vito Foderà, Hanne Mørck Nielsen
Format: Article
Language:English
Published: MDPI AG 2020-10-01
Series:Pharmaceutics
Subjects:
intestinal peptide delivery
insulin
PTH(1-34)
cell-penetrating peptide
penetratin
carrier peptide
Online Access:https://www.mdpi.com/1999-4923/12/10/993

Internet

https://www.mdpi.com/1999-4923/12/10/993

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