The Phage-Encoded <i>N</i>-Acetyltransferase Rac Mediates Inactivation of <i>Pseudomonas aeruginosa</i> Transcription by Cleavage of the RNA Polymerase Alpha Subunit

The Phage-Encoded <i>N</i>-Acetyltransferase Rac Mediates Inactivation of <i>Pseudomonas aeruginosa</i> Transcription by Cleavage of the RNA Polymerase Alpha Subunit

In this study, we describe the biological function of the phage-encoded protein RNA polymerase alpha subunit cleavage protein (Rac), a predicted Gcn5-related acetyltransferase encoded by phiKMV-like viruses. These phages encode a single-subunit RNA polymerase for transcription of their late (structu...

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Bibliographic Details
Main Authors: Pieter-Jan Ceyssens, Jeroen De Smet, Jeroen Wagemans, Natalia Akulenko, Evgeny Klimuk, Subray Hedge, Marleen Voet, Hanne Hendrix, Jan Paeshuyse, Bart Landuyt, Hua Xu, John Blanchard, Konstantin Severinov, Rob Lavigne
Format: Article
Language:English
Published: MDPI AG 2020-09-01
Series:Viruses
Subjects:
phage-induced acetylation
host transcriptional shutdown
phage–host interactions
Online Access:https://www.mdpi.com/1999-4915/12/9/976

Internet

https://www.mdpi.com/1999-4915/12/9/976

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