Evidence for Non-Cancer-Specific T Cell Exhaustion in the Tcl1 Mouse Model for Chronic Lymphocytic Leukemia

Evidence for Non-Cancer-Specific T Cell Exhaustion in the Tcl1 Mouse Model for Chronic Lymphocytic Leukemia

The reinvigoration of anti-cancer immunity by immune checkpoint therapies has greatly improved cancer treatment. In chronic lymphocytic leukemia (CLL), patients as well as in the Tcl1 mouse model for CLL, PD1-expressing, exhausted T cells significantly expand alongside CLL development; nevertheless,...

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Bibliographic Details
Main Authors: Thomas Parigger, Franz Josef Gassner, Christian Scherhäufl, Aryunni Abu Bakar, Jan Philip Höpner, Alexandra Hödlmoser, Markus Steiner, Kemal Catakovic, Roland Geisberger, Richard Greil, Nadja Zaborsky
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:International Journal of Molecular Sciences
Subjects:
CLL
T cell exhaustion
Tcl1
Online Access:https://www.mdpi.com/1422-0067/22/13/6648

Internet

https://www.mdpi.com/1422-0067/22/13/6648

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