Laminin-associated integrins mediate Diffuse Intrinsic Pontine Glioma infiltration and therapy response within a neural assembloid model

Laminin-associated integrins mediate Diffuse Intrinsic Pontine Glioma infiltration and therapy response within a neural assembloid model

Abstract Diffuse Intrinsic Pontine Glioma (DIPG) is a highly aggressive and fatal pediatric brain cancer. One pre-requisite for tumor cells to infiltrate is adhesion to extracellular matrix (ECM) components. However, it remains largely unknown which ECM proteins are critical in enabling DIPG adhesio...

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Bibliographic Details
Main Authors: Sauradeep Sinha, Michelle S. Huang, Georgios Mikos, Yudhishtar Bedi, Luis Soto, Sarah Lensch, Manish Ayushman, Lacramioara Bintu, Nidhi Bhutani, Sarah C. Heilshorn, Fan Yang
Format: Article
Language:English
Published: BMC 2024-05-01
Series:Acta Neuropathologica Communications
Subjects:
Diffuse Intrinsic Pontine Glioma
Neural organoids
Extracellular matrix
Integrins
Laminin
Online Access:https://doi.org/10.1186/s40478-024-01765-4

Internet

https://doi.org/10.1186/s40478-024-01765-4

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