NOTCH1 mutation associates with impaired immune response and decreased relapse-free survival in patients with resected T1-2N0 laryngeal cancer

NOTCH1 mutation associates with impaired immune response and decreased relapse-free survival in patients with resected T1-2N0 laryngeal cancer

BackgroundPatients with early-stage laryngeal cancer, even stage T1-2N0, are at considerable risk of recurrence and death. The genetic and immunologic characteristics of recurrent laryngeal cancer remain unclear.MethodsA total of 52 T1-2N0 laryngeal cancer patients were enrolled. Of these, 42 tissue...

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Bibliographic Details
Main Authors: Xiao-yang Gong, Hai-bin Chen, Li-qing Zhang, Dong-sheng Chen, Wang Li, Dong-hui Chen, Jin Xu, Han Zhou, Le-le Zhao, Yun-jie Song, Ming-zhe Xiao, Wang-long Deng, Chuang Qi, Xue-rong Wang, Xi Chen
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-07-01
Series:Frontiers in Immunology
Subjects:
T1-2N0 laryngeal cancer
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tumor mutation burden
NOTCH1 mutation
tumor immunity
molecular alterations
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.920253/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2022.920253/full

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