Oxygen microcapsules improve immune checkpoint blockade by ameliorating hypoxia condition in pancreatic ductal adenocarcinoma

Oxygen microcapsules improve immune checkpoint blockade by ameliorating hypoxia condition in pancreatic ductal adenocarcinoma

Rationale: Hypoxia in tumor microenvironment (TME) represents an obstacle to the efficacy of immunotherapy for pancreatic ductal adenocarcinoma (PDAC) through several aspects such as increasing the expression of immune checkpoints or promoting fibrosis. Reversing hypoxic TME is a potential strategy...

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Bibliographic Details
Main Authors: Jiangchao Wu, Xun Wang, Li Chen, Jianing Wang, Junlei Zhang, Jianghui Tang, Yongtao Ji, Jinyuan Song, Lin Wang, Yaxing Zhao, Hui Zhang, Taohong Li, Jianpeng Sheng, Dong Chen, Qi Zhang, Tingbo Liang
Format: Article
Language:English
Published: KeAi Communications Co., Ltd. 2023-02-01
Series:Bioactive Materials
Subjects:
Hypoxia
PD-1
Tumor microenvironment
Pancreatic ductal adenocarcinoma
Oxygen microcapsules
Online Access:http://www.sciencedirect.com/science/article/pii/S2452199X22002420

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http://www.sciencedirect.com/science/article/pii/S2452199X22002420

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