Heat Treatment Induced Specified Aggregation Morphology of Metoprolol Tartrate in Poly(ε-caprolactone) Matrix and the Drug Release Variation

Heat Treatment Induced Specified Aggregation Morphology of Metoprolol Tartrate in Poly(ε-caprolactone) Matrix and the Drug Release Variation

Hot-melt blending has been widely used in the pharmaceutical industry to produce drug delivery systems, however, realizing the controlled drug release behavior of a hot-melt blended medicament it is still a tough challenge. In this study, we developed a simple and effective heat treatment method to...

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Bibliographic Details
Main Authors: Zhiyu Liu, Hangling Song, Xia Chen, Aichun Han, Rong Chen, Guiting Liu, Shaoyun Guo
Format: Article
Language:English
Published: MDPI AG 2021-09-01
Series:Polymers
Subjects:
aggregation morphology
drug diffusion channel
drug release variation
hot-melt blending
isothermal heat treatment
metoprolol
Online Access:https://www.mdpi.com/2073-4360/13/18/3076

Internet

https://www.mdpi.com/2073-4360/13/18/3076

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