Carnosine Potentiates Doxorubicin-Induced Cytotoxicity in Resistant NCI/ADR-RES Cells by Inhibiting P-Glycoprotein—In Silico and In Vitro Evidence

Carnosine Potentiates Doxorubicin-Induced Cytotoxicity in Resistant NCI/ADR-RES Cells by Inhibiting P-Glycoprotein—In Silico and In Vitro Evidence

The activity of the P-glycoprotein (P-gp) transporter encoded by the ABCB1 gene confers resistance to anticancer drugs and contributes to cancer-related mortality and morbidity. Recent studies revealed the cytotoxic effects of the endogenous dipeptide carnosine. The current study aimed to investigat...

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Bibliographic Details
Main Authors: Mohamed A. Morsy, Mahmoud Kandeel, Ahmed R. N. Ibrahim, Seham A. Abdel-Gaber, Shery Jacob, Katharigatta N. Venugopala, Pottathil Shinu, Mahmoud El-Daly
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:Molecules
Subjects:
P-glycoprotein
carnosine
multidrug resistance
doxorubicin
molecular dynamics simulations
cancer chemotherapy
Online Access:https://www.mdpi.com/1420-3049/27/21/7383

Internet

https://www.mdpi.com/1420-3049/27/21/7383

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