Rolling circle RNA synthesis catalyzed by RNA

RNA-catalyzed RNA replication is widely considered a key step in the emergence of life’s first genetic system. However, RNA replication can be impeded by the extraordinary stability of duplex RNA products, which must be dissociated for re-initiation of the next replication cycle. Here, we have explo...

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Bibliographic Details
Main Authors: Emil Laust Kristoffersen, Matthew Burman, Agnes Noy, Philipp Holliger
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2022-02-01
Series:eLife
Subjects:
Online Access:https://elifesciences.org/articles/75186