Peptide Antibody Reactivity to Homologous Regions in Glutamate Decarboxylase Isoforms and Coxsackievirus B4 P2C

Peptide Antibody Reactivity to Homologous Regions in Glutamate Decarboxylase Isoforms and Coxsackievirus B4 P2C

Two isoforms of the glutamate decarboxylase (GAD) enzyme exist, GAD65 and GAD67, which are associated with type 1 diabetes (T1D) and stiff-person syndrome (SPS), respectively. Interestingly, it has been reported that T1D patients seldom develop SPS, whereas patients with SPS occasionally develop T1D...

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Bibliographic Details
Main Authors: Nicole Hartwig Trier, Niccolo Valdarnini, Ilaria Fanelli, Paolo Rovero, Paul Robert Hansen, Claus Schafer-Nielsen, Evaldas Ciplys, Rimantas Slibinskas, Flemming Pociot, Tina Friis, Gunnar Houen
Format: Article
Language:English
Published: MDPI AG 2022-04-01
Series:International Journal of Molecular Sciences
Subjects:
antibody cross-reactivity
coxsackievirus
glutamate decarboxylase
peptide antibodies
stiff-person syndrome
type 1 diabetes
Online Access:https://www.mdpi.com/1422-0067/23/8/4424

Internet

https://www.mdpi.com/1422-0067/23/8/4424

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