Spontaneous Right Ventricular Pseudoaneurysms and Increased Arrhythmogenicity in a Mouse Model of Marfan Syndrome

Spontaneous Right Ventricular Pseudoaneurysms and Increased Arrhythmogenicity in a Mouse Model of Marfan Syndrome

Patients with Marfan syndrome (MFS), a connective tissue disorder caused by pathogenic variants in the gene encoding the extracellular matrix protein fibrillin-1, have an increased prevalence of primary cardiomyopathy, arrhythmias, and sudden cardiac death. We have performed an in-depth in vivo and...

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Bibliographic Details
Main Authors: Felke Steijns, Marjolijn Renard, Marine Vanhomwegen, Petra Vermassen, Jana Desloovere, Robrecht Raedt, Lars E. Larsen, Máté I. Tóth, Julie De Backer, Patrick Sips
Format: Article
Language:English
Published: MDPI AG 2020-09-01
Series:International Journal of Molecular Sciences
Subjects:
marfan syndrome
fibrillin-1
cardiac function
myocardial compaction
ventricular pseudoaneurysm
electrocardiogram
Online Access:https://www.mdpi.com/1422-0067/21/19/7024

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https://www.mdpi.com/1422-0067/21/19/7024

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