Systemic inactivation of hypoxia-inducible factor prolyl 4-hydroxylase 2 in mice protects from alcohol-induced fatty liver disease

Systemic inactivation of hypoxia-inducible factor prolyl 4-hydroxylase 2 in mice protects from alcohol-induced fatty liver disease

Alcoholic fatty liver disease (AFLD) is a growing health problem for which no targeted therapy is available. We set out to study whether systemic inactivation of the main hypoxia-inducible factor prolyl 4-hydroxylase, HIF-P4H-2 (PHD2/EglN1), whose inactivation has been associated with protection aga...

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Bibliographic Details
Main Authors: Anna Laitakari, Teemu Ollonen, Thomas Kietzmann, Gail Walkinshaw, Daniela Mennerich, Valerio Izzi, Kirsi-Maria Haapasaari, Johanna Myllyharju, Raisa Serpi, Elitsa Y. Dimova, Peppi Koivunen
Format: Article
Language:English
Published: Elsevier 2019-04-01
Series:Redox Biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231718312588

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http://www.sciencedirect.com/science/article/pii/S2213231718312588

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