Identification of Trypanosoma cruzi Polyamine Transport Inhibitors by Computational Drug Repurposing

Identification of Trypanosoma cruzi Polyamine Transport Inhibitors by Computational Drug Repurposing

Trypanosoma cruzi is the causative agent of Chagas disease, a parasitic infection endemic in Latin America. In T. cruzi the transport of polyamines is essential because this organism is unable to synthesize these compounds de novo. Therefore, the uptake of polyamines from the extracellular medium is...

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Bibliographic Details
Main Authors: Chantal Reigada, Melisa Sayé, Otto Phanstiel, Edward Valera-Vera, Mariana R. Miranda, Claudio A. Pereira
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-11-01
Series:Frontiers in Medicine
Subjects:
Trypanosoma cruzi
Chagas disease
polyamine transport
drug repositioning
trypanocidal drugs
polyamines
Online Access:https://www.frontiersin.org/article/10.3389/fmed.2019.00256/full

Internet

https://www.frontiersin.org/article/10.3389/fmed.2019.00256/full

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