Stroma-derived IL-6, G-CSF and Activin-A mediated dedifferentiation of lung carcinoma cells into cancer stem cells

Stroma-derived IL-6, G-CSF and Activin-A mediated dedifferentiation of lung carcinoma cells into cancer stem cells

Abstract Cancer stem cells (CSCs) are a small population of resistant cells inhabiting the tumors. Although comprising only nearly 3% of the tumor mass, these cells were demonstrated to orchestrate tumorigenesis and differentiation, underlie tumors’ heterogeneity and mediate therapy resistance and t...

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Bibliographic Details
Main Authors: Carlos F. D. Rodrigues, Eurico Serrano, Maria I. Patrício, Mariana M. Val, Patrícia Albuquerque, João Fonseca, Célia M. F. Gomes, Antero J. Abrunhosa, Artur Paiva, Lina Carvalho, M. Filomena Botelho, Luís Almeida, Isabel M. Carreira, Maria Carmen Alpoim
Format: Article
Language:English
Published: Nature Portfolio 2018-08-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-018-29947-w

Internet

https://doi.org/10.1038/s41598-018-29947-w

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