Targeting cancer homing into the lymph node with a novel anti-CCR7 therapeutic antibody: the paradigm of CLL

Targeting cancer homing into the lymph node with a novel anti-CCR7 therapeutic antibody: the paradigm of CLL

Lymph node (LN) is a key tissue in the pathophysiology of mature blood cancers, especially for chronic lymphocytic leukemia (CLL). Within the multiple de-regulated pathways affecting CLL homeostasis, the CC-chemokine receptor 7 (CCR7) grants homing of CLL cells into the LN where protective environme...

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Bibliographic Details
Main Authors: Carlos Cuesta-Mateos, Raquel Juárez-Sánchez, Tamara Mateu-Albero, Javier Loscertales, Wim Mol, Fernando Terrón, Cecilia Muñoz-Calleja
Format: Article
Language:English
Published: Taylor & Francis Group 2021-01-01
Series:mAbs
Subjects:
CCR7
CLL
antibody
CAP-100
immunotherapy
lymph node
Online Access:https://www.tandfonline.com/doi/10.1080/19420862.2021.1917484

Internet

https://www.tandfonline.com/doi/10.1080/19420862.2021.1917484

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