Normalization and variance stabilization of single-cell RNA-seq data using regularized negative binomial regression

Normalization and variance stabilization of single-cell RNA-seq data using regularized negative binomial regression

Abstract Single-cell RNA-seq (scRNA-seq) data exhibits significant cell-to-cell variation due to technical factors, including the number of molecules detected in each cell, which can confound biological heterogeneity with technical effects. To address this, we present a modeling framework for the no...

Disgrifiad llawn

Manylion Llyfryddiaeth
Prif Awduron:	Christoph Hafemeister, Rahul Satija
Fformat:	Erthygl
Iaith:	English
Cyhoeddwyd:	BMC 2019-12-01
Cyfres:	Genome Biology
Pynciau:	Single-cell RNA-seq Normalization
Mynediad Ar-lein:	https://doi.org/10.1186/s13059-019-1874-1

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