Normalization and variance stabilization of single-cell RNA-seq data using regularized negative binomial regression

Normalization and variance stabilization of single-cell RNA-seq data using regularized negative binomial regression

Abstract Single-cell RNA-seq (scRNA-seq) data exhibits significant cell-to-cell variation due to technical factors, including the number of molecules detected in each cell, which can confound biological heterogeneity with technical effects. To address this, we present a modeling framework for the no...

Cur síos iomlán

Sonraí bibleagrafaíochta
Príomhchruthaitheoirí:	Christoph Hafemeister, Rahul Satija
Formáid:	Alt
Teanga:	English
Foilsithe / Cruthaithe:	BMC 2019-12-01
Sraith:	Genome Biology
Ábhair:	Single-cell RNA-seq Normalization
Rochtain ar líne:	https://doi.org/10.1186/s13059-019-1874-1

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