Normalization and variance stabilization of single-cell RNA-seq data using regularized negative binomial regression
Abstract Single-cell RNA-seq (scRNA-seq) data exhibits significant cell-to-cell variation due to technical factors, including the number of molecules detected in each cell, which can confound biological heterogeneity with technical effects. To address this, we present a modeling framework for the no...
| Principais autores: | , |
|---|---|
| Formato: | Artigo |
| Idioma: | English |
| Publicado em: |
BMC
2019-12-01
|
| coleção: | Genome Biology |
| Assuntos: | |
| Acesso em linha: | https://doi.org/10.1186/s13059-019-1874-1 |