Mechanism of the interaction between the intrinsically disordered C-terminus of the pro-apoptotic ARTS protein and the Bir3 domain of XIAP.

Mechanism of the interaction between the intrinsically disordered C-terminus of the pro-apoptotic ARTS protein and the Bir3 domain of XIAP.

ARTS (Sept4_i2) is a mitochondrial pro-apoptotic protein that functions as a tumor suppressor. Its expression is significantly reduced in leukemia and lymphoma patients. ARTS binds and inhibits XIAP (X-linked Inhibitor of Apoptosis protein) by interacting with its Bir3 domain. ARTS promotes degradat...

Full description

Bibliographic Details
Main Authors: Tali H Reingewertz, Deborah E Shalev, Shahar Sukenik, Ofrah Blatt, Shahar Rotem-Bamberger, Mario Lebendiker, Sarit Larisch, Assaf Friedler
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3176765?pdf=render

Internet

http://europepmc.org/articles/PMC3176765?pdf=render

Similar Items