Epigenomic and clinical analyses of striatal DAT binding in healthy individuals reveal well-known loci of Parkinson's disease

Epigenomic and clinical analyses of striatal DAT binding in healthy individuals reveal well-known loci of Parkinson's disease

Background: Striatal dopamine transporter (DAT) binding is a sensitive and specific endophenotype for detecting dopaminergic deficits across Parkinson's disease (PD) spectrum. Molecular and clinical signatures of PD in asymptomatic phases help understand the earliest pathophysiological mechanis...

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Bibliographic Details
Main Authors: Arash Yaghoobi, Homa Seyedmirzaei, Marzie Jamaat, Moein Ala
Format: Article
Language:English
Published: Elsevier 2024-12-01
Series:Heliyon
Subjects:
DAT scan
Parkinson's disease
Epigenome-wide association study
Cognitive domains
Healthy individuals
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844024166492

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http://www.sciencedirect.com/science/article/pii/S2405844024166492

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