A mutation in the tuft mouse disrupts TET1 activity and alters the expression of genes that are crucial for neural tube closure

A mutation in the tuft mouse disrupts TET1 activity and alters the expression of genes that are crucial for neural tube closure

Genetic variations affecting neural tube closure along the head result in malformations of the face and brain. Neural tube defects (NTDs) are among the most common birth defects in humans. We previously reported a mouse mutant called tuft that arose spontaneously in our wild-type 3H1 colony. Adult t...

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Bibliographic Details
Main Authors: Keith S. K. Fong, Robert B. Hufnagel, Vedbar S. Khadka, Michael J. Corley, Alika K. Maunakea, Ben Fogelgren, Zubair M. Ahmed, Scott Lozanoff
Format: Article
Language:English
Published: The Company of Biologists 2016-05-01
Series:Disease Models & Mechanisms
Subjects:
Anterior cranial cephalocele
Midfacial cleft
Neural tube defect
Encephalocele
Exencephaly
Anencephaly
Epigenetic
Online Access:http://dmm.biologists.org/content/9/5/585

Internet

http://dmm.biologists.org/content/9/5/585

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