Site Selective Antibody-Oligonucleotide Conjugation via Microbial Transglutaminase

Site Selective Antibody-Oligonucleotide Conjugation via Microbial Transglutaminase

Nucleic Acid Therapeutics (NATs), including siRNAs and AntiSense Oligonucleotides (ASOs), have great potential to drug the undruggable genome. Targeting siRNAs and ASOs to specific cell types of interest has driven dramatic improvement in efficacy and reduction in toxicity. Indeed, conjugation of tr...

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Bibliographic Details
Main Authors: Ian J. Huggins, Carlos A. Medina, Aaron D. Springer, Arjen van den Berg, Satish Jadhav, Xianshu Cui, Steven F. Dowdy
Format: Article
Language:English
Published: MDPI AG 2019-09-01
Series:Molecules
Subjects:
oligonucleotide therapeutics
siRNA
antisense oligonucleotides
monoclonal antibodies
antibody-siRNA conjugate (ARC)
microbial transglutaminase
copper-less click
Online Access:https://www.mdpi.com/1420-3049/24/18/3287

Internet

https://www.mdpi.com/1420-3049/24/18/3287

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