First quantitative high-throughput screen in zebrafish identifies novel pathways for increasing pancreatic β-cell mass

First quantitative high-throughput screen in zebrafish identifies novel pathways for increasing pancreatic β-cell mass

Whole-organism chemical screening can circumvent bottlenecks that impede drug discovery. However, in vivo screens have not attained throughput capacities possible with in vitro assays. We therefore developed a method enabling in vivo high-throughput screening (HTS) in zebrafish, termed automated rep...

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Bibliographic Details
Main Authors: Guangliang Wang, Surendra K Rajpurohit, Fabien Delaspre, Steven L Walker, David T White, Alexis Ceasrine, Rejji Kuruvilla, Ruo-jing Li, Joong S Shim, Jun O Liu, Michael J Parsons, Jeff S Mumm
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2015-07-01
Series:eLife
Subjects:
high-throughput screening
whole-organism drug discovery
beta cell
diabetes
NF-κB
serotonin
Online Access:https://elifesciences.org/articles/08261

Internet

https://elifesciences.org/articles/08261

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