Effects of bergapten on the pharmacokinetics of macitentan in rats both in vitro and in vivo

Effects of bergapten on the pharmacokinetics of macitentan in rats both in vitro and in vivo

Macitentan was approved by the United States Food and Drug Administration (FDA) in 2013 for the treatment of pulmonary arterial hypertension (PAH). Bergapten is a furanocoumarin that is abundant in Umbelliferae and Rutaceae plants and is widely used in many Chinese medicine prescriptions. Considerin...

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Bibliographic Details
Main Authors: Jia Xu, Quan Zhou, Pengjiao Hou, Yu Wang, Peiwu Geng, Zebei Lu, Yunfang Zhou, Dapeng Dai, Shuanghu Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-07-01
Series:Frontiers in Pharmacology
Subjects:
pulmonary arterial hypertension
macitentan
bergapten
drug-drug interaction
pharmacokinetics
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2023.1204649/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2023.1204649/full

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