The Deinococcus protease PprI senses DNA damage by directly interacting with single-stranded DNA
Abstract Bacteria have evolved various response systems to adapt to environmental stress. A protease-based derepression mechanism in response to DNA damage was characterized in Deinococcus, which is controlled by the specific cleavage of repressor DdrO by metallopeptidase PprI (also called IrrE). De...
Main Authors: | , , , , , , , , , , , |
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Format: | Article |
Language: | English |
Published: |
Nature Portfolio
2024-02-01
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Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/s41467-024-46208-9 |