Exploring the multi-target enzyme inhibition potential of new sulfonamido-thiazoline derivatives; synthesis and computational studies

Exploring the multi-target enzyme inhibition potential of new sulfonamido-thiazoline derivatives; synthesis and computational studies

A small library of ten new Nimesulide-iminothiazolines conjugates was synthesized by the reduction of nitro group of Nimesulide followed by conversion into variously substituted acyl thioureas. Heterocyclization of the latter with phenacyl bromide afforded the products (7a-j) in good to excellent yi...

Full description

Bibliographic Details
Main Authors: Imran Shafique, Aamer Saeed, Atteeque Ahmed, Ghulam Shabir, Anwar Ul-Hamıd, Ajmal Khan, Burak Tüzün, Mahinur Kirici, Parham Taslimi, Muhammad Latif
Format: Article
Language:English
Published: Elsevier 2022-01-01
Series:Results in Chemistry
Subjects:
Nimesulide
Acetylcholinesterase
Butyrylcholinesterase
Carbonic anhydrase I
Carbonic anhydrase II
Enzyme inhibition
Online Access:http://www.sciencedirect.com/science/article/pii/S2211715622003757

Internet

http://www.sciencedirect.com/science/article/pii/S2211715622003757

Similar Items