Editing of mouse and human immunoglobulin genes by CRISPR-Cas9 system
CRISPR-Cas9 has been used to generate a range of genetic modifications including gene knock-outs and chromosomal rearrangements. Here the authors target the immunogloblin genes and demonstrate the induction of class switch recombination, opening up possibilities for research and antibody production.
Main Authors: | , , |
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Format: | Article |
Language: | English |
Published: |
Nature Portfolio
2016-03-01
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Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/ncomms10934 |