Hypermethylation of CD19 promoter enables antigen-negative escape to CART-19 in vivo and in vitro

Hypermethylation of CD19 promoter enables antigen-negative escape to CART-19 in vivo and in vitro

Background Anti-CD19 chimeric antigen receptor T cells (CART-19) frequently induce remissions in hemato-oncological patients with recurred and/or refractory B-cell tumors. However, malignant cells sometimes escape the immunotherapeutic targeting by CD19 gene mutations, alternative splicing or lineag...

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Bibliographic Details
Main Authors: Veronika Mancikova, Helena Peschelova, Veronika Kozlova, Aneta Ledererova, Adriana Ladungova, Jan Verner, Tomas Loja, Sarka Pospisilova, Michal Smida, Lenka Dostalova, Martin Culen
Format: Article
Language:English
Published: BMJ Publishing Group 2021-08-01
Series:Journal for ImmunoTherapy of Cancer
Online Access:https://jitc.bmj.com/content/9/8/e002352.full

Internet

https://jitc.bmj.com/content/9/8/e002352.full

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