Neuronal excitatory-to-inhibitory balance is altered in cerebral organoid models of genetic neurological diseases

Neuronal excitatory-to-inhibitory balance is altered in cerebral organoid models of genetic neurological diseases

Abstract The neuro-physiological properties of individuals with genetic pre-disposition to neurological disorders are largely unknown. Here we aimed to explore these properties using cerebral organoids (COs) derived from fibroblasts of individuals with confirmed genetic mutations including PRNP E200...

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Bibliographic Details
Main Authors: Simote T. Foliaki, Benjamin Schwarz, Bradley R. Groveman, Ryan O. Walters, Natalia C. Ferreira, Christina D. Orrù, Anna Smith, Aleksandar Wood, Olivia M. Schmit, Phoebe Freitag, Jue Yuan, Wenquan Zou, Catharine M. Bosio, James A. Carroll, Cathryn L. Haigh
Format: Article
Language:English
Published: BMC 2021-10-01
Series:Molecular Brain
Subjects:
Neurodegenerative diseases
Neuronal network communication
Neural oscillation
Online Access:https://doi.org/10.1186/s13041-021-00864-w

Internet

https://doi.org/10.1186/s13041-021-00864-w

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