Characterization of Monoclonal Antibody Glycan Heterogeneity Using Hydrophilic Interaction Liquid Chromatography-Mass Spectrometry

Characterization of Monoclonal Antibody Glycan Heterogeneity Using Hydrophilic Interaction Liquid Chromatography-Mass Spectrometry

Glycosylation is a critical quality attribute of monoclonal antibody (mAb) therapeutics. Hydrophilic interaction liquid chromatography-mass spectrometry (HILIC-MS) is an invaluable technology for the characterization of protein glycosylation. HILIC/MS-based glycan analysis relies on the library sear...

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Bibliographic Details
Main Authors: Sumit K. Singh, Kelvin H. Lee
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-01-01
Series:Frontiers in Bioengineering and Biotechnology
Subjects:
glycosylation
glycan
monoclonal antibody
CHO cell
hydrophilic interaction liquid chromatography
Online Access:https://www.frontiersin.org/articles/10.3389/fbioe.2021.805788/full

Internet

https://www.frontiersin.org/articles/10.3389/fbioe.2021.805788/full

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