Excess filaggrin in keratinocytes is removed by extracellular vesicles to prevent premature death and this mechanism can be hijacked by Staphylococcus aureus in a TLR2‐dependent fashion

Excess filaggrin in keratinocytes is removed by extracellular vesicles to prevent premature death and this mechanism can be hijacked by Staphylococcus aureus in a TLR2‐dependent fashion

Abstract Filaggrin (FLG) protein is indispensable for multiple aspects of the epidermal barrier function but its accumulation in a monomeric filaggrin form may initiate premature keratinocytes death; it is unclear how filaggrin levels are controlled before the formation of storing keratohyalin granu...

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Bibliographic Details
Main Authors: Adrian Kobiela, Lilit Hovhannisyan, Paulina Jurkowska, Jorge Bernardino dela Serna, Aleksandra Bogucka, Milena Deptuła, Argho Aninda Paul, Kinga Panek, Ewa Czechowska, Michał Rychłowski, Aleksandra Królicka, Jacek Zieliński, Susanne Gabrielsson, Michał Pikuła, Magdalena Trzeciak, Graham S Ogg, Danuta Gutowska‐Owsiak
Format: Article
Language:English
Published: Wiley 2023-06-01
Series:Journal of Extracellular Vesicles
Subjects:
atopic dermatitis
bacteria
exosomes
extracellular vesicles
filaggrin
keratinocyte
Online Access:https://doi.org/10.1002/jev2.12335

Internet

https://doi.org/10.1002/jev2.12335

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