Boosting synergism of chemo- and immuno-therapies via switching paclitaxel-induced apoptosis to mevalonate metabolism-triggered ferroptosis by bisphosphonate coordination lipid nanogranules

Boosting synergism of chemo- and immuno-therapies via switching paclitaxel-induced apoptosis to mevalonate metabolism-triggered ferroptosis by bisphosphonate coordination lipid nanogranules

Conventional chemotherapy based on cytotoxic drugs is facing tough challenges recently following the advances of monoclonal antibodies and molecularly targeted drugs. It is critical to inspire new potential to remodel the value of this classical therapeutic strategy. Here, we fabricate bisphosphonat...

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Bibliographic Details
Main Authors: Ge Song, Minghui Li, Shumin Fan, Mengmeng Qin, Bin Shao, Wenbing Dai, Hua Zhang, Xueqing Wang, Bing He, Qiang Zhang
Format: Article
Language:English
Published: Elsevier 2024-02-01
Series:Acta Pharmaceutica Sinica B
Subjects:
Bisphosphonate coordination lipid nanogranules
Ferroptosis
Mevalonate metabolism
Mitochondrial metabolism
Nano-systematic biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383523003362

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http://www.sciencedirect.com/science/article/pii/S2211383523003362

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