Dynamic Metabolic Changes During Prolonged Ex Situ Heart Perfusion Are Associated With Myocardial Functional Decline

Dynamic Metabolic Changes During Prolonged Ex Situ Heart Perfusion Are Associated With Myocardial Functional Decline

Ex situ heart perfusion (ESHP) was developed to preserve and evaluate donated hearts in a perfused beating state. However, myocardial function declines during ESHP, which limits the duration of perfusion and the potential to expand the donor pool. In this research, we combine a novel, minimally-inva...

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Bibliographic Details
Main Authors: Mariola Olkowicz, Roberto Vanin Pinto Ribeiro, Frank Yu, Juglans Souto Alvarez, Liming Xin, Miao Yu, Roizar Rosales, Mitchell Brady Adamson, Ved Bissoondath, Ryszard T. Smolenski, Filio Billia, Mitesh Vallabh Badiwala, Janusz Pawliszyn
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-06-01
Series:Frontiers in Immunology
Subjects:
heart transplantation (HTx)
ex situ heart perfusion
immunity response
solid phase microextraction (SPME)
metabolomics
lipidomics
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.859506/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2022.859506/full

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