Soluble HMGB1 is a novel adipokine stimulating IL-6 secretion through RAGE receptor in SW872 preadipocyte cell line: contribution to chronic inflammation in fat tissue.

Soluble HMGB1 is a novel adipokine stimulating IL-6 secretion through RAGE receptor in SW872 preadipocyte cell line: contribution to chronic inflammation in fat tissue.

Low-grade inflammation (LGI) is a central phenomenon in the genesis of obesity and insulin-resistance characterized by IL-6 in human serum. Whereas this LGI was initially thought to be mainly attributed to macrophage activation, it is now known that pre-adipocytes and adipocytes secrete several adip...

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Bibliographic Details
Main Authors: Brice Nativel, Mery Marimoutou, Vincent G Thon-Hon, Manoj Kumar Gunasekaran, Jessica Andries, Giovédie Stanislas, Cynthia Planesse, Christine Robert Da Silva, Maya Césari, Thomas Iwema, Philippe Gasque, Wildriss Viranaicken
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3779194?pdf=render

Internet

http://europepmc.org/articles/PMC3779194?pdf=render

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