Heteronemin and Tetrac Induce Anti-Proliferation by Blocking EGFR-Mediated Signaling in Colorectal Cancer Cells

Heteronemin and Tetrac Induce Anti-Proliferation by Blocking EGFR-Mediated Signaling in Colorectal Cancer Cells

Overexpressed EGFR and mutant <i>K-Ras</i> play vital roles in therapeutic resistance in colorectal cancer patients. To search for an effective therapeutic protocol is an urgent task. A secondary metabolite in the sponge <i>Hippospongia</i> sp., Heteronemin, has been shown to...

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Bibliographic Details
Main Authors: Sukanya Unson, Tung-Cheng Chang, Yung-Ning Yang, Shwu-Huey Wang, Chi-Hung Huang, Dana R. Crawford, Haw-Ming Huang, Zi-Lin Li, Hung-Yun Lin, Jacqueline Whang-Peng, Kuan Wang, Paul J. Davis, Wen-Shan Li
Format: Article
Language:English
Published: MDPI AG 2022-07-01
Series:Marine Drugs
Subjects:
heteronemin
tetrac
colorectal cancer
<i>KRAS</i>
EGFR signaling
Online Access:https://www.mdpi.com/1660-3397/20/8/482

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https://www.mdpi.com/1660-3397/20/8/482

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