Co-expression of a SARP Family Activator ChlF2 and a Type II Thioesterase ChlK Led to High Production of Chlorothricin in Streptomyces antibioticus DSM 40725

Co-expression of a SARP Family Activator ChlF2 and a Type II Thioesterase ChlK Led to High Production of Chlorothricin in Streptomyces antibioticus DSM 40725

Chlorothricin (CHL), produced by Streptomyces antibioticus DSM 40725 (wild-type strain, WT), belongs to a growing family of spirotetronate antibiotics that have biological activities inhibiting pyruvate carboxylase and malate dehydrogenase. ChlF2, a cluster-situated SARP regulator, can activate the...

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Bibliographic Details
Main Authors: Yue Li, Jihui Zhang, Jiazhen Zheng, Hanye Guan, Wen Liu, Huarong Tan
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-08-01
Series:Frontiers in Bioengineering and Biotechnology
Subjects:
Streptomyces antibioticus
gene regulation
chlorothricin
high production
halogenase
Online Access:https://www.frontiersin.org/article/10.3389/fbioe.2020.01013/full

Internet

https://www.frontiersin.org/article/10.3389/fbioe.2020.01013/full

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