The emerging double-edged sword role of Sirtuins in the gastric inflammation-carcinoma sequence revealed by bulk and single-cell transcriptomes

The emerging double-edged sword role of Sirtuins in the gastric inflammation-carcinoma sequence revealed by bulk and single-cell transcriptomes

Histone modification and the inflammation-carcinoma sequence (ICS) have been acknowledgedly implicated in gastric carcinogenesis. However, the extremum expression of some histone modification genes (HMGs) in intestinal metaplasia (IM) rather than GC obscures the roles of HMGs in ICS. In this study,...

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Bibliographic Details
Main Authors: Mengyang Wang, Chenxiao Bi, Hong Li, Lizhen Lu, Tao Gao, Panpan Huang, Chengxia Liu, Bin Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-10-01
Series:Frontiers in Oncology
Subjects:
inflammation-carcinoma sequence
gastric cancer
histone modification
Sirtuins
histone deacetylase
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2022.1004726/full

Internet

https://www.frontiersin.org/articles/10.3389/fonc.2022.1004726/full

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