Metformin May Alter the Metabolic Reprogramming in Cancer Cells by Disrupting the L-Arginine Metabolism: A Preliminary Computational Study

Metformin May Alter the Metabolic Reprogramming in Cancer Cells by Disrupting the L-Arginine Metabolism: A Preliminary Computational Study

Metabolic reprogramming in cancer is considered to be one of the most important hallmarks to drive proliferation, angiogenesis, and invasion. AMP-activated protein kinase activation is one of the established mechanisms for metformin’s anti-cancer actions. However, it has been suggested that metformi...

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Bibliographic Details
Main Authors: Bryan Alejandro Espinosa-Rodriguez, Daniela Treviño-Almaguer, Pilar Carranza-Rosales, Monica Azucena Ramirez-Cabrera, Karla Ramirez-Estrada, Eder Ubaldo Arredondo-Espinoza, Luis Fernando Mendez-Lopez, Isaias Balderas-Renteria
Format: Article
Language:English
Published: MDPI AG 2023-03-01
Series:International Journal of Molecular Sciences
Subjects:
metformin
L-arginine
cancer
creatine
biguanides
metabolism
Online Access:https://www.mdpi.com/1422-0067/24/6/5316

Internet

https://www.mdpi.com/1422-0067/24/6/5316

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