Hsp90β inhibition upregulates interferon response and enhances immune checkpoint blockade therapy in murine tumors

Hsp90β inhibition upregulates interferon response and enhances immune checkpoint blockade therapy in murine tumors

Response resistance to the immune checkpoint blockade (ICB) immunotherapy remains a major clinical challenge that may be overcome through the rational combination of ICB and specific targeted therapeutics. One emerging combination strategy is based on sensitizing ICB-refractory tumors with antagonis...

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Bibliographic Details
Main Authors: Sharif Rahmy, Sanket J. Mishra, Sean Murphy, Brian S. J. Blagg, Xin Lu
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-10-01
Series:Frontiers in Immunology
Subjects:
heat shock protein 90 (hsp90)
isoform-selective inhibitor
immune checkpoint blockade (ICB)
prostate cancer
breast cancer
CDK4/6
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.1005045/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2022.1005045/full

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