Both SUMOylation and ubiquitination of TFE3 fusion protein regulated by androgen receptor are the potential target in the therapy of Xp11.2 translocation renal cell carcinoma

Both SUMOylation and ubiquitination of TFE3 fusion protein regulated by androgen receptor are the potential target in the therapy of Xp11.2 translocation renal cell carcinoma

ABSTRACT Background The aggressiveness of renal cell carcinoma (RCC) associated with Xp11.2 translocation/TFE3 gene fusion (Xp11.2 translocation RCC [Xp11.2 tRCC]) is age‐dependent, which is similar to the overall trend of reproductive endocrine hormones. Therefore, this study focused on the effect...

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Bibliographic Details
Main Authors: Ning Liu, Yi Chen, Lei Yang, Qiancheng Shi, Yanwen Lu, Wenliang Ma, Xiaodong Han, Hongqian Guo, Dongmei Li, Weidong Gan
Format: Article
Language:English
Published: Wiley 2022-04-01
Series:Clinical and Translational Medicine
Subjects:
progression
SUMOylation
TFE3
translocation RCC
ubiquitination
Online Access:https://doi.org/10.1002/ctm2.797

Internet

https://doi.org/10.1002/ctm2.797

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